R ESEARCH R EPORT No 03 . 07 June 2003 RNA sequences and the EDIT ( NESTED , NESTED ) problem
نویسندگان
چکیده
In molecular biology, RNA structure comparison is of great interest to help solving problems as different as phylogeny reconstruction, prediction of molecule folding and identification of a function common to a set of molecules. Lin and al. [13] proposed to define a similarity criterion between RNA structures using a concept of edit distance. They proved that computing the edit distance is a Max-SNP hard problem when at least one of the structures is tertiary. Besides, they gave a polynomial algorithm when at least one of the structures is primary. Until now remained open the question of the existence of an exact polynomial algorithm for the problem EDIT(NESTED, NESTED). This problem, as shown by Lin and al. [13], corresponds to computing the edit distance between two secondary structures. In this paper, we prove that this problem is NP-Complete. General Terms: Algorithms Additional
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